Chromosome Y Microdeletion
Infertility is a major health problem affecting 10-15% of couples seeking to have children and a male factor can be identified in about half of these cases. A significant proportion of infertile males are affected either by oligozoospermia or azoospermia.
The recent growth of assisted reproduction techniques has led to the identification of Y chromosome microdeletions into AZF regions correlated to non-obstructive azoospermia, Men with deletions in AZFa and AZFb regions show severe defects in spermatogenesis, whereas deletions of AZFc region can be compatible with residual spermatogenesis.
These Clonit tests are based on Gel Electrophoresis and Reverse Hybridization techniques.