CE MarkEER018032
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The apolipoprotein E (ApoE) is a 299 aminoacid glycoprotein synthesized in the liver and nervous system, in surrenal gland, gonads, kidney, musculus striatum and spleen. The three possible alleles of ApoE (E2,E3, E4) encode for the E2, E3 ed E4 isoforms respectively.

In the brain Apo E plays a crucial role in the development and repairment of neuronal structures. Moreover, Apo E is involved in the pathogenesis of the either late onset, familiar or sporadic Alzheimer’s Disease.