32 Tests - A4070G
Available for QiaSymphony SP/AS - Ref: EER31032QS
Factor V H1299R
DuplicαRealTime Next Factor V H1299R Kit is an in vitro diagnostic test for the detection of the nucleotide substitution A4070G of the blood coagulation Factor V gene, by Real-Time PCR.
Thrombophilia is a multigenic disorder caused by inherited and acquired defects. Individuals with multiple defects have a highly increased risk of development of Deep Venous Thrombosis (DVT). The A4070G (FV1299 His-Arg) polymorphism of the Factor V gene (FV; this allele is a part of R2 haplotype) in exon 13 was recently shown to influence circulating FV levels and to contribute to the Activated Protein C (APC) resistance phenotype. Heterozygous of both FV G1691A and FV A4070G substitutions is associated with a significant increasing risk of developing DVT (3-4 times if compared with the single FV R506Q substitution).
- Nucleotide substitution A4070G in the human Factor V gene
- Internal Control (IC)
- Peripheral whole blood samples collected in EDTA
Compatible with the most common DNA Extraction and Purification Systems
Real-Time PCR instruments:
Compatible with the most common Real-Time PCR Systems