Code
EER041032
CE MarkEER041032
Tests

32 Tests - A4070G

Available for QiaSymphony SP/AS - Ref: EER31032QS

Factor V H1299R

Thrombophilia is a multigenic disorder caused by inherited and acquired defects. Individuals with multiple defects have a highly increased risk of development of Deep Venous Thrombosis (DVT). The A4070G (FV1299 His-Arg) polymorphism of the Factor V gene (FV; this allele is a part of R2 haplotype) in exon 13 was recently shown to influence circulating FV levels and to contribute to the Activated Protein C (APC) resistance phenotype. Heterozygous of both FV G1691A and FV A4070G substitutions is associated with a significant increasing risk of developing DVT (3-4 times if compared with the single FV R506Q substitution).