Available for QiaSymphony SP/AS - Ref: EER049032QS
Increased plasma fibrinogen levels have been identified as a risk indicator for myocardial infarction, stroke, and thrombosis. Both environmental and genetic factors make an important contribution to plasma fibrinogen levels in humans. Fibrinogen (Factor I) is a glycoprotein, synthesized in the liver, that participates in the coagulation cascade.
Fibrinogen converts to fibrin in the presence of thrombin. Elevated fibrinogen levels have been associated with increased risk for atherosclerosis and deep venous thrombosis as well as cardiovascular diseases. Fibrinogen is composed of three pairs of polypeptide chains (named α, β and γ) which are linked by disulfide bonds.
These three chains are encoded by three different genes (α, β and γ, respectively), that are located on chromosome 4. Among genetic factors, a common G → A polymorphism at position - 455 in the promoter region of the Beta -Fibrinogen gene has been associated with elevated fibrinogen levels (for the AA homozygous carriers).