32 Tests - V34L
Coagulation factor XIII (FXIII) is a plasma transglutaminase circulating as an inactive tetramer of two catalytic A subunits and two accessory B-subunits (A2B2). Activated FXIII (FXIIIa) plays various physiologic roles in several fields from haemostasis to wound healing and pregnancy, and its defects are associated with bleeding complications after surgery or trauma, inefficient wound healing, and risk of miscarriage.
The main physiologic task of FXIIIa is fibrin cross-linking during the final steps of blood coagulation to increase clot mechanical strength against fibrinolysis. Physiologic FXIIIa substrates belong to different categories, from the coagulation and fibrinolytic system, to the adhesive proteins involved into the assembling of extracellular matrix (ECM), to the contractile/cytoskeletal proteins. In addition, FXIIIA-subunit is thought to function in various processes involving cell proliferation and tissue remodelling.
A FXIIIA polymorphism (FXIII V34L) has been described as increasing the activity and modifying the cross-linking properties of FXIII conferring protection against thrombosis and predisposition to intracerebral haemorrhage.