CE MarkRT-101

24 Tests

AML1-ETO t(8;21)(q22;q22)

Acute myeloid leukemia (AML) with the t(8;21) (q22;q22) creating the AML1-ETO fusion gene is a distinct type of AML generally associated with a favorable prognosis.

The translocation  t(8;21)(q22;q22)  generates a fusion gene located on the derivative chromosome 8, composed of the ETO gene on chromosome 8 and the AML1 gene (also known as RUNX1) on chromosome 21. The AML1-ETO fusion gene and its transcripts can be detected by reverse transcriptase–polymerase chain reaction (RT-PCR). The detection of the AML1-ETO fusion gene allows patients to be assigned to the appropriate risk group for management.